|
KMID : 0377619740270050441
|
|
Korean Jungang Medical Journal
1974 Volume.27 No. 5 p.441 ~ p.449
|
|
|
Studies on Hypnotic Sedatives-Induced Fatty Accumulation in Rats
|
|
|
|
|
Abstract
|
|
|
Administration of three hypnotic sedatives to rats fed a standard laborarory diet and five different diets affected the levels of triglyceride, phospholipid and cholesterol in the liver and serum, and the levels of lipase in the serum and pancrea. Phenobarbital and amobarbital produced the elevated levels of hepatic lipids and serum triglyceride, but not affected the levels of serum phospholid and cholesterol.
Chlorpromazine did not affected the levels of serum and hepatic lipids. Choline,. Fat and protein contents in these diets were factors influencing the triglyceride accumulation in the liver as a result of phenobarbital and amobarbital. However, these dietary factors did not to regulate the manner in which phenobarbital and amobarbital elevated phospholipid and total cholesterol levels in the liver.
The level of serum lipase was elevated by administration of amobarbital, and the level of pancreatic lipase was decreased by administration of chloropromazine.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|